This Guide provides resources for locally-led, inclusive, multisectoral upgrading for climate resilience in urban informal settlements. Designed as a guide not a toolkit, it pays particular attention to context and its variation across cities and countries — the principles, guides and methods in this document must be translated to each unique context. It can help replicate the approaches and roles taken by institutions and people for comprehensive, transformative upgrading — based largely on the experience from the Mukuru Special Planning Area (SPA) in Nairobi, Kenya — but not the specific plans themselves. While the focus is on Africa, the lessons can be applied elsewhere as well.